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Pharmacy Benefit Management System (PBMS)

PBMS Background

Historically, Colorado’s Pharmacy Benefit Management System (PBMS) has been managed as one solution with one vendor. Prime Healthcare (formerly known as Magellan) has been the vendor for Colorado’s PBMS since 2017. Prime’s contract ends in February 2026.

PBMS Transition

The legacy PBMS, implemented in 2017, is the foundation for five PBMS modules that will be implemented in the CMES ecosystem.

The table below provides an overview of the PBMS modules and their anticipated changes.

Module 

Current Vendor 

New Vendor 

Go Live 

Pharmacy Benefit Management System

Prime Therapeutics 

MedImpact

Winter 2026

Rebate Administration

Fall 2025 

Preferred Drug List

Fall 2025 

Real-Time Benefit Tool

Winter 2026

Opioid Risk

OpiSafe

OpiSafe

N/A

What is changing?

Four modules are being transitioned from the current vendor, Prime Therapeutics (Prime), to a new vendor, MedImpact. The transition of the PBMS modules to MedImpact will enable flexibility, configurability, scalability, and interoperability for the pharmacy program. The modules transitioning from Prime to MedImpact are:

  • Pharmacy Benefit Management System
  • Rebate Administration
  • Preferred Drug List
  • Real-Time Benefit Tool

What is staying the same?

The Opioid Risk module will remain with the current vendor, OpiSafe. 

Send questions or comments to hcpf_cmes@state.co.us.